Thimerosal: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Thimerosal?

Thimerosal is a synthetic compound that belongs to the organomercury family, formally known as mercurate(1-) ethyl[2-mercaptobenzoato(2-)-O S]- sodium. In simpler terms it is a chemical that combines ethyl mercury with a type of salicylic acid and sodium. First introduced in the late 1920s as a germ killer for topical products it quickly found a place in personal care items that needed help staying fresh on the shelf. Commercial production starts with reacting ethyl chloride with sodium thiosalicylate in the presence of mercury salts, then purifying the resulting salt into a fine, water-soluble powder.

Thimerosal shows up most often in products that contain a lot of water which makes them prone to bacterial growth. You might see it in certain lotions, liquid makeup, cleansing milks, toners, face masks and specialty treatments that are packaged for multiple uses. Because regulations and consumer preferences vary many brands have switched to other options, but it is still permitted in small amounts in some regions where long-term preservation is needed.

Thimerosal’s Cosmetic Benefits/Uses

In cosmetics thimerosal serves one core purpose that supports both product quality and user safety.

As a preservative it keeps bacteria mold and yeast from growing in the formula which helps the product last longer, stay stable and remain safe to use over its advertised shelf life. By preventing microbial contamination it also protects the skin from potential infections that could arise from spoiled products.

Who Can Use Thimerosal

Because thimerosal is added only to keep a formula free of germs rather than to treat the skin itself it is generally considered suitable for oily, combination, normal and even dry skin. Sensitive or allergy-prone users may want to steer clear since organomercury compounds are a well-known trigger for contact dermatitis in a small group of people.

The ingredient is synthesized in a lab and contains no animal-derived materials so it can fit into vegan and vegetarian lifestyles. That said cruelty-free status depends on the finished brand’s animal-testing policies rather than the preservative alone.

Pregnant or breastfeeding individuals should be cautious because thimerosal is an organomercury compound and mercury exposure is a concern during fetal or infant development. The trace amounts allowed in cosmetics are considered low risk yet this is not medical advice and anyone expecting or nursing should speak with a healthcare professional before using products that list thimerosal.

Thimerosal does not make the skin more prone to sunburn and has no known effect on UV sensitivity. It also plays nicely with most common skincare ingredients since it stays dissolved in the water phase and does not interfere with actives.

Potential Side Effects/Adverse Reactions

Reactions to topical thimerosal differ from person to person. The points below outline potential issues and most people will not encounter them when the preservative is used within regulated limits.

  • Allergic contact dermatitis
  • Redness stinging or itching at the application site
  • Swelling or blistering in individuals already sensitized to mercury
  • Eye irritation if the product accidentally gets into the eyes
  • Cumulative mercury absorption with very frequent or large-area use, though this is rare in cosmetic settings
  • Interaction with other mercury-containing products potentially raising total exposure

If any discomfort or unusual reaction occurs stop using the product immediately and consult a qualified healthcare professional.

Comedogenic Rating

Rating: 0/5

Thimerosal is water soluble and used at very low concentrations so it does not leave an oily film or create the kind of surface barrier that can trap sebum or debris in pores. Because it does not clog pores it is generally considered safe for people who are prone to acne or breakouts.

No data link thimerosal to increased comedone formation and its antimicrobial action might even help keep the finished product cleaner in the jar which indirectly supports clearer skin.

Summary

Thimerosal is a preservative that defends cosmetic formulas against bacteria mold and yeast. It does this by releasing small amounts of ethyl mercury ions that disrupt microbial cell processes and keep the product stable over time.

Once a go to option in watery lotions toners and multi use masks thimerosal has lost ground to newer preservatives because many consumers prefer mercury free labels and some regions regulate its use tightly.

Within the legal limits set by health authorities thimerosal is regarded as safe for topical use on intact skin though anyone pregnant breastfeeding or highly sensitive should consult a professional before use. As with any cosmetic ingredient it is wise to patch test a new product to check for individual reactions.

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