Thiodiglycol: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Thiodiglycol?

Thiodiglycol, also called 2,2′-thiodiethanol, is a clear liquid made from combining ethylene oxide with hydrogen sulfide followed by careful purification. Chemically it contains two alcohol groups and one sulfur atom, a mix that lets it blend well with both water and oil. First used decades ago as an industrial solvent and dye helper, it later caught the eye of cosmetic chemists because it can boost product stability and keep delicate ingredients from breaking down. Today you may spot thiodiglycol in lightweight serums, soothing moisturizers, anti aging creams, rinse off masks and even some makeup products that need a little extra shelf life.

Thiodiglycol’s Cosmetic Benefits/Uses

In skin care formulas thiodiglycol serves mainly one role, but it is a valuable one.

As an antioxidant it helps protect the finished product from oxygen damage, which keeps the color, scent and performance of a lotion or cream consistent from the first pump to the last. By slowing down oxidation it indirectly supports the stability of other active ingredients so the formula stays effective for longer.

Who Can Use Thiodiglycol

Because thiodiglycol is lightweight and non greasy it generally suits all skin types including dry, normal, combination and oily. Sensitive skin also tends to tolerate it since it is used at low levels and does not disturb the skin barrier. There are no specific skin types that should avoid it unless an individual has a known allergy to the ingredient.

Thiodiglycol is manufactured from petrochemical feedstocks rather than animal derivatives so it is suitable for both vegans and vegetarians. Ethical buyers should still look for cruelty free certification from the finished brand if that is important to them.

Available safety data shows no evidence that topical thiodiglycol poses a special risk to women who are pregnant or breastfeeding when used in normal cosmetic concentrations. This is not medical advice and anyone who is expecting or nursing should always ask a qualified healthcare provider before starting any new skincare product just to be on the safe side.

The ingredient does not increase photosensitivity. Standard daytime sun protection habits are still recommended but no extra precautions are needed specifically because of thiodiglycol.

Potential Side Effects/Adverse Reactions

Reactions to topical thiodiglycol can vary from person to person. The points below outline potential side effects that have been reported or are theoretically possible. They remain uncommon for most users when the ingredient is formulated correctly.

  • Mild stinging or burning on application especially on freshly exfoliated or compromised skin
  • Temporary redness or warmth which should subside quickly once the product is absorbed
  • Contact dermatitis in individuals who are allergic to sulfur containing compounds
  • Watery eyes or irritation if the product is accidentally rubbed into the eye area
  • Unpleasant sulfur like odor in rare cases where high concentrations are used although this is more a cosmetic concern than a health risk

If any persistent irritation or other negative reaction occurs discontinue use immediately and consult a healthcare professional.

Comedogenic Rating

Rating: 0/5 (non comedogenic)

Thiodiglycol is fully water miscible and leaves almost no residue on the skin. It contains no heavy oils, waxes or fatty acids so it cannot create the kind of occlusive film that traps dead cells and sebum in pores. For these reasons it is considered non comedogenic.

Because it does not clog pores it is generally a safe choice for people who are prone to acne or frequent breakouts.

No studies or user feedback suggest that thiodiglycol worsens blackheads, whiteheads or cystic acne even at the upper use levels allowed in cosmetics.

Summary

Thiodiglycol acts mainly as an antioxidant that slows down the oxidation of delicate ingredients which helps creams, serums and makeup keep their color, scent and performance for longer. Its small dual alcohol structure lets it mix with both water and oil phases so it can patrol the entire formula for rogue oxygen without separating.

The ingredient is more of a behind the scenes helper than a headline act so it is not as famous as hyaluronic acid or vitamin C. You will usually spot it low on an ingredient list rather than splashed across the front label, yet formulators value it for the reliability it brings.

Current safety data shows a low risk profile with rare reports of irritation or allergy. Even so every skin chemistry is unique so it is wise to patch test any new product that contains thiodiglycol before using it over a larger area.

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