What Is Tranexamoyl Dipeptide-22?
Tranexamoyl Dipeptide-22 is a lab made ingredient formed when tranexamic acid is chemically linked with a tiny chain of two amino acids known as Dipeptide-22. Tranexamic acid itself is a synthetic version of the natural amino acid lysine while the dipeptide is built through standard peptide synthesis. When the two are joined their combined structure becomes more stable and easier for skin care formulas to use.
The brightening talent of tranexamic acid was first noticed in the medical field in the 1970s. Over time cosmetic chemists began to explore it as a gentler option for fading dark spots. To boost its skin affinity they bonded it to small peptides and the result was Tranexamoyl Dipeptide-22. Since the early 2010s this hybrid has found its way into many modern brightening products.
Manufacturing starts with making each piece separately under controlled lab conditions. The finished dipeptide is then reacted with tranexamic acid using safe coupling agents. After purification the white to off-white powder is ready to be blended into cosmetic bases.
You will most often see Tranexamoyl Dipeptide-22 in lightweight serums, dark spot correctors, sheet masks, brightening creams, anti-aging lotions and post-sun treatments where an even skin tone is the goal.
Tranexamoyl Dipeptide-22’s Cosmetic Benefits/Uses
This ingredient’s main job is to support a clearer more even complexion.
Its bleaching action helps slow the transfer of extra pigment to the skin surface, which in turn can reduce the look of age spots, sun spots and other forms of discoloration. Regular use in a formula may lead to a brighter, more uniform skin tone without the harshness sometimes linked to stronger lightening agents.
Who Can Use Tranexamoyl Dipeptide-22
Most skin types tolerate Tranexamoyl Dipeptide-22 well. Its gentle nature makes it a good match for normal, dry, oily and combination skin. Sensitive skin users usually cope fine too because the molecule works without heavy exfoliation or strong acids. Those with a known allergy to peptides or tranexamic acid derivatives should steer clear since even a small dose could trigger a reaction.
The ingredient is made entirely through synthetic chemistry so no animal parts or by-products are involved. That means it is suitable for both vegans and vegetarians, provided the finished product has not been tested on animals by the brand.
Current data shows no links between topical Tranexamoyl Dipeptide-22 and problems during pregnancy or breastfeeding. Even so, research on expectant and nursing mothers is limited. This is not medical advice and anyone who is pregnant or lactating should run any skincare they plan to use past a qualified healthcare professional just to be safe.
The molecule does not increase photosensitivity. Daily sunscreen is still wise because UV light is a main driver behind the dark spots you are trying to fade. Tranexamoyl Dipeptide-22 also mixes well with most common actives such as niacinamide and vitamin C, helping create flexible routines.
Potential Side Effects/Adverse Reactions
Responses to topical Tranexamoyl Dipeptide-22 vary from person to person. The points below list potential side effects yet they remain uncommon when the ingredient is used at the levels normally found in cosmetics.
- Mild redness or irritation
- Temporary stinging or warmth at the point of application
- Dryness or slight flaking if the product is layered too frequently
- Allergic reaction such as itching hives or swelling in rare cases
- Heightened irritation when combined with strong acids or high strength retinoids
If any of these effects appear and do not settle quickly discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0–1
Tranexamoyl Dipeptide-22 is a small, water-soluble molecule with no oily or waxy backbone so it does not linger in pores or form surface films that could trap debris. Finished formulas usually contain it at low percentages and in fluid textures like serums or gels, further lowering clogging risk. Because of this the ingredient is considered non-comedogenic and is unlikely to trigger blackheads or whiteheads.
Suitability for acne-prone skin: generally safe and well tolerated.
No additional pore-blocking concerns are linked to this peptide though the overall comedogenicity of a product still depends on the rest of the ingredient list.
Summary
Tranexamoyl Dipeptide-22 is a lab crafted blend of tranexamic acid and a short peptide that targets uneven tone. It slows excess pigment release within the skin so dark spots fade and overall brightness improves without harsh exfoliation. The peptide link boosts stability and skin affinity allowing steady, gentle performance.
While not as famous as niacinamide or vitamin C it is gaining traction in new wave brightening serums and masks because consumers want milder alternatives to hydroquinone. More brands are adding it to multi-tasking formulas, so availability is growing but it is still a niche star rather than a household name.
Safety data show a low irritation profile, no photo-reactivity and minimal risk of clogged pores. Serious reactions are rare yet, as with any new skincare ingredient, patch testing is wise to rule out individual sensitivities before regular use.