What Is Tripeptide-23?
Tripeptide-23 is a lab-made chain of three amino acids: glycine, proline and threonine. Because it is synthetic, it is not harvested from plants or animals but produced in controlled facilities through solid-phase peptide synthesis, a process that links amino acids one by one to create a precise sequence. Peptides began gaining traction in skin care in the late 1990s when researchers found that short chains of amino acids could signal skin cells to behave in a more youthful way. As interest in peptide technology grew, formulators developed Tripeptide-23 for its ability to condition and support the skin surface. Today you will spot it in a range of products like anti-aging serums, firming creams, sheet masks, eye treatments and hydrating moisturizers where a gentle yet effective skin conditioning agent is desired.
Tripeptide-23’s Cosmetic Benefits/Uses
Tripeptide-23 appears on ingredient lists mainly for one reason: skin conditioning. By helping skin feel softer and look smoother, it can improve the overall sensory feel of a product and give the complexion a healthier appearance. When blended into a formula with moisturizers and protective agents, it supports the skin barrier and enhances the performance of the entire product.
Who Can Use Tripeptide-23
Because Tripeptide-23 is gentle and has no known pore clogging properties, it suits most skin types including normal, dry, combination, oily and mature skin. People with very sensitive or easily reactive skin often tolerate it well since it does not contain fragrances or common irritants. There are no reports of it being unsuitable for specific skin types, although anyone with a history of peptide allergies should be cautious.
As the peptide is produced entirely in a lab without animal by-products, it is considered appropriate for vegans and vegetarians.
No published data link Tripeptide-23 with harmful effects during pregnancy or while breastfeeding. Still, research on topical peptides in these groups is limited. This information is not medical advice; pregnant or nursing women should review any skincare product with their healthcare provider to stay on the safe side.
The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. It also plays nicely with most other skincare actives, allowing it to slot easily into morning or evening routines.
Potential Side Effects/Adverse Reactions
Individual reactions to topical Tripeptide-23 can vary. The points below outline potential side effects, yet most users will not encounter them when the ingredient is formulated and used correctly.
- Mild redness or warmth shortly after application
- Temporary itching or tingling as the product absorbs
- Localized irritation on broken or compromised skin
- Rare allergic contact dermatitis presenting as persistent rash or swelling
- Stinging if the formula accidentally gets into the eyes
If any uncomfortable reaction occurs stop using the product and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Comedogenic rating: 0. Tripeptide-23 is a small water-soluble molecule that does not contain heavy oils, waxes or fatty acids known to block pores, so it earns a non-comedogenic score. This makes it suitable for those prone to acne or breakouts. As always the overall pore-clogging potential of a finished product depends on the entire formula, not just one ingredient.
Summary
Tripeptide-23 is a lab-crafted trio of amino acids that conditions skin by helping it feel softer, look smoother and better retain moisture. It does this by supporting the skin surface and working alongside hydrators and barrier-strengthening agents.
While not as famous as peptides like Matrixyl or copper peptides it is quietly appearing in more serums, creams and masks thanks to its gentle performance and vegan profile.
Current data show Tripeptide-23 is safe for most skin types with a very low risk of irritation or comedogenicity. Even so it is wise to patch test any new product to rule out personal sensitivities before applying it to the full face.