Vitis Vinifera/Labrusca Stem Extract: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Vitis Vinifera/Labrusca Stem Extract?

Vitis Vinifera/Labrusca Stem Extract comes from the woody stems of a grapevine hybrid made by crossing the common wine grape Vitis vinifera with the hardy North American Vitis labrusca. These stems are rich in natural sugars, organic acids, polyphenols and small amounts of minerals that together give the extract its skin-friendly qualities. Grape growers have long regarded pruned stems as waste, but researchers discovered that the same antioxidant compounds prized in grape skins and seeds are also present in the stalks, sparking interest in upcycling this by-product for skincare.

The extract is produced by drying and finely milling the stems, then soaking them in a food-grade solvent such as glycerin or water. The liquid pulls out water-soluble antioxidants and humectant sugars, after which the mixture is filtered and concentrated. The result is a clear to amber fluid that blends easily into both water-based and emulsion formulas.

You will typically find Vitis Vinifera/Labrusca Stem Extract in mattifying moisturizers, lightweight gels for oily or combination skin, anti-aging serums, sheet masks and daily lotions that aim to protect against environmental stress. Formulators also use it in after-sun products and soothing mists.

Vitis Vinifera/Labrusca Stem Extract’s Cosmetic Benefits/Uses

This multitasking ingredient brings several helpful functions to a formula:

  • Anti-Sebum: Helps balance excess oil on the skin surface, leaving a fresher matte finish that can reduce midday shine
  • Humectant: Draws moisture from the air into the outer layer of skin, supporting a soft hydrated feel without heaviness
  • Skin Protecting: Delivers natural antioxidants that can neutralize free radicals generated by pollution and UV exposure, helping guard against premature signs of aging
  • Solvent: Assists in dissolving other water-soluble ingredients, promoting an even distribution of actives across the skin

Who Can Use Vitis Vinifera/Labrusca Stem Extract

Thanks to its lightweight humectant qualities and oil-balancing action, this extract suits oily, combination and normal skin particularly well. Sensitive and mature complexions usually tolerate it too because the polyphenols are calming antioxidants. Very dry skin can still benefit from its water-binding sugars but will likely need a richer occlusive on top since the ingredient itself does not supply heavy lipids.

Because it is obtained solely from plant stems using food-grade solvents, Vitis Vinifera/Labrusca Stem Extract is compatible with vegan and vegetarian lifestyles. No animal derivatives are introduced at any step of production.

No studies indicate special concerns for pregnant or breastfeeding women when the extract is used topically in cosmetic amounts. This is not medical advice and women who are expecting or nursing should ask their healthcare provider before adding any new product to their routine, just to be on the safe side.

The extract is not known to cause photosensitivity. In fact its antioxidant content may offer a mild supportive benefit when paired with daily sunscreen. It is also non-comedogenic, making it a friendly choice for acne-prone users who want hydration without clogged pores.

Potential Side Effects/Adverse Reactions

Individual responses to topical Vitis Vinifera/Labrusca Stem Extract can differ. The issues listed below are possible but uncommon for the average user when the ingredient is properly formulated.

  • Skin irritation such as mild redness or itching
  • Transient stinging on freshly exfoliated or broken skin
  • Allergic contact dermatitis in users sensitive to grape or other botanical phenolics
  • Interaction with strong actives like high-percentage acids or retinoids that may heighten overall sensitivity

If you experience persistent discomfort, rinse the area with water, discontinue use and seek medical advice if needed.

Comedogenic Rating

Rating: 0 / 5

Vitis Vinifera/Labrusca Stem Extract is almost entirely made of water-soluble antioxidants, sugars and trace minerals with virtually no heavy oils or waxes that could block pores. Because it is lightweight and typically used at low percentages in watery gels or serums, it has no realistic tendency to form a film that traps sebum or debris. For these reasons its comedogenic rating is a clear 0, making it suitable for skin that is prone to acne or breakouts.

The only caveat is that a finished product’s overall formula counts more than any single ingredient. If the extract sits in a rich cream full of pore-clogging oils, that product could still be comedogenic even though the extract itself is not.

Summary

Vitis Vinifera/Labrusca Stem Extract serves four main roles in skincare: it balances excess oil, pulls water into the upper layers of skin, delivers antioxidant protection and helps dissolve other water-based actives. Its polyphenols mop up free radicals while natural sugars act as humectants and mild sebum regulators, all without adding greasy residue.

The ingredient is gaining moderate popularity, especially among brands highlighting upcycled plant parts and eco-friendly sourcing, yet it is not as common as grape seed extract or resveratrol. Still, formulators appreciate its multitasking nature and light skin feel.

Overall safety is high, with rare reports of irritation or allergy mostly limited to those sensitive to grape derivatives. As with any new cosmetic, patch testing a small area first is a smart way to confirm personal compatibility before full-face use.

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