What Is R-Clostridium Histolyticum Collagenase G Hexapeptide-40?
R-Clostridium Histolyticum Collagenase G Hexapeptide-40 is a lab-made peptide created by combining the genetic instructions for two different proteins, Collagenase G from the bacterium Clostridium histolyticum and a smaller fragment known as Hexapeptide-40. Scientists first explored these kinds of fusion peptides for medical research, then discovered that their skin-friendly traits could be useful in beauty formulas. To produce it, technicians insert the custom-built gene into harmless E. coli, let the bacteria grow in large fermenters, then harvest and purify the resulting 1 124-amino-acid chain. The final ingredient is a fine, water-soluble powder that blends easily into creams and serums. Brands now add it to anti-aging moisturizers, firming eye creams, leave-on masks, concentrated treatment ampoules and post-procedure soothing gels where a gentle boost to skin texture is desired.
R-Clostridium Histolyticum Collagenase G Hexapeptide-40’s Cosmetic Benefits/Uses
This peptide is prized for one main role in topical formulas.
As a skin-conditioning agent it helps the surface of the skin feel softer, smoother and more supple. By supporting the natural renewal of the outer layer, it can improve overall texture, reduce the look of rough patches and enhance the way a product spreads and absorbs, giving a more pleasant user experience.
Who Can Use R-Clostridium Histolyticum Collagenase G Hexapeptide-40
This peptide is considered gentle enough for most skin types, including dry, normal, combination, oily and sensitive skin, because it focuses on surface conditioning without strong exfoliating or occlusive actions. Those with very compromised or broken skin barriers should wait until the area is healed since even mild actives can cause discomfort on raw skin.
Because the ingredient is produced by fermentation in E. coli and contains no animal derived materials it qualifies as suitable for vegans and vegetarians.
No specific data link the peptide to problems during pregnancy or while breastfeeding. There is also no suggestion it penetrates deeply enough to reach the bloodstream in meaningful amounts. Still, this is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product they plan to use to their doctor just to be safe.
The peptide is not known to increase photosensitivity, so it does not make skin more prone to sunburn. Standard daytime sun protection habits should still be followed.
Potential Side Effects/Adverse Reactions
Responses to topical R-Clostridium Histolyticum Collagenase G Hexapeptide-40 vary from person to person. The points below list potential side effects that could occur even though most users will not experience them when the ingredient is formulated and used correctly.
- Transient redness or warmth
- Mild itching or tingling
- Localized stinging on freshly shaved or irritated skin
- Allergic contact dermatitis in individuals sensitive to peptides or fermentation by-products
- Interaction with potent exfoliants or retinoids leading to increased irritation in very sensitive users
If any unwanted reaction develops stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
This peptide is a large, water-soluble molecule that sits on the skin’s surface rather than sinking into pores or creating an oily film. It has no fatty or waxy components that could block follicles, so it earns the lowest possible score on the comedogenic scale.
Because it does not clog pores it is considered suitable for people who are prone to acne or breakouts.
No other comedogenic concerns have been flagged in the available safety data or manufacturer reports.
Summary
R-Clostridium Histolyticum Collagenase G Hexapeptide-40 is a lab-crafted fusion peptide used mainly for skin conditioning. By supporting the natural turnover of the outer layer it helps skin feel softer and look smoother while improving the glide and absorption of creams and serums. Its large water-loving structure keeps it on the surface where it can do its job without clogging pores or penetrating too deeply.
The ingredient is still relatively niche and tends to appear in targeted anti-aging or post-procedure formulas rather than mass-market products, though interest is growing as brands look for new gentle actives.
Safety profiles show a low risk of irritation or allergy when properly formulated, making the peptide broadly suitable for most skin types. As with any new skincare ingredient it is wise to perform a small patch test before full use to ensure personal compatibility.